海带多糖对环磷酰胺诱发小鼠骨髓细胞微核率的抑制作用

doi:10.3969/j.issn.1004-616x.1999.02.016

Carcinogenesis, Teratogenesis & Mutagenesis ›› 1999, Vol. 11 ›› Issue (2): 106-107.doi: 10.3969/j.issn.1004-616x.1999.02.016

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INHIBITORY EFFECT OF LAMINARIA J APONICA POLYSACCHARIDES INHIBITORY EFFECT OF LAMINARIA J APONICA POLYSACCHARIDES

Wang Tingxin , Qin Shuzheng , Zhao wen , J iang Dongsheng , Ma Xiaotong , Bian Qiangrong

HeBei S anitary Epidemic S tation , Baoding 　071000

Received:1998-09-15 Revised:1998-11-21 Online:1999-03-30 Published:1999-03-30

Abstract

Abstract: Inhibitory effect of L aminaria japonica polysacchrides (L PS) on micronucleus rate induced by cyclophosphamide (CP) had been studied by mean of micronucleus test in mouse bonemarrow polychromatic erythrocyte (PCE) . Micronucleus rates of positive cont rol group (CP 40mg/ kg. bw) , and three L PS tested groups (L PS 500mg/ kg , 1000mg/ kg , 2000mg/ kg) was 28 ‰, 22 ‰, 12 ‰, 11 ‰, respectively. There were significant differences tested groups (1000mg/ kg , 2000mg/ kg) as compared with positive cont rol group. The results showed that L PS possessed inhibitory effect s on mutagenesis indued by cyclophamide.

Key words: L aminaria japonica polysaccharides, cyclophosphamide, micronucleus rates

Wang Tingxin , Qin Shuzheng , Zhao wen , J iang Dongsheng , Ma Xiaotong , Bian Qiangrong. INHIBITORY EFFECT OF LAMINARIA J APONICA POLYSACCHARIDES INHIBITORY EFFECT OF LAMINARIA J APONICA POLYSACCHARIDES[J]. Carcinogenesis, Teratogenesis & Mutagenesis, 1999, 11(2): 106-107.

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[2]	YANG Run-fang，GUO Hai-dong，XIA Qi-yue，LIU Qiang-qiang，XU Ce，ZHUO Yan-qiang，LI Hong-xia. Cyclophosphamide as a positive control in teratogenicity test of rats [J]. Carcinogenesis, Teratogenesis & Mutagenesis, 2013, 25(3): 222-226.
[3]	ZHOU Chang-hui1,WANG Zheng1,WANG Qing-li2,YANG Chen-mao1,CHANG Yan1,*. Three-color labeling method for flow cytometric measurement of micronucleus in mouse peripheral blood [J]. , 2011, 23(2): 128-133.
[4]	WU You-ping, ZHANG Sheng, CHEN Yan-hong, WU Hong-hai, YU Ya-nan. Changes of Immunological Function after Two Separate Injections of Cyclophosphamidec in SD Rats [J]. Carcinogenesis, Teratogenesis & Mutagenesis, 2009, 21(6): 443-446.
[5]	SONG Wen-tao, MA Zhi-min, , JI Shou-lian, LIU Guang-ming, SHI Gui-rong. Micronucleus Test of Vicia Faba L. Root Tip Cells to Assess the Anti-mutation Property of Periplaneta Americana and Aspongopus Chinensis Dallas Mixture [J]. Carcinogenesis, Teratogenesis & Mutagenesis, 2008, 20(6): 475-476.
[6]	LIU Zhong-ping, PANG Hui-min, ZHAO Yun-xiao, ZHU Yu-zhuo, . Preliminary Study on Antimutag-enesis and Antioxidation of Aqueous Extract of Pulsatilla Chinensis Regel [J]. Carcinogenesis, Teratogenesis & Mutagenesis, 2008, 20(6): 481-482.
[7]	XIAO Kai, LI Hong-xia. Effects of Cyclophosphamide Dose and Sampling Time on Mouse Micronucleus Frequency in Bone Marrow [J]. Carcinogenesis, Teratogenesis & Mutagenesis, 2005, 17(6): 367-369.
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[9]	ZHU Wei-yun, PANG Zhu-lin, LIANG Min-yi, et al. THE EFFECT OF TARAXACUM MONGO TO INHIBIT THE MUTATION IN THE BONE MARROW LYMPHOCYTE OF MICE INDUCED BY CYCLOPHOSPHAMIDE [J]. Carcinogenesis, Teratogenesis & Mutagenesis, 2003, 15(3): 164-167.
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[13]	GUAN Xiao - ju , et al. CELLULAR EFFECTS OF CYCLOPHOSPHAMIDE ON MOUSE EMBRYOS FROM WHOLE EMBRYO CULTURE SYSTEM [J]. Carcinogenesis, Teratogenesis & Mutagenesis, 2000, 12(3): 145-148.
[14]	SHI Chang , LIAO Ming-yang. EFFECT OF CYCLOPHOSPHAMIDE AND IFOSFAMIDE ON THE FREQUENCIES OF MICRONUCLEUS IN PREGNANCY MICE [J]. Carcinogenesis, Teratogenesis & Mutagenesis, 2000, 12(1): 37-039.
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INHIBITORY EFFECT OF LAMINARIA J APONICA POLYSACCHARIDES INHIBITORY EFFECT OF LAMINARIA J APONICA POLYSACCHARIDES

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